May 20 – 23, 2019
Discovery Building on the University of Wisconsin-Madison Campus
America/Chicago timezone

Studying RNA Virus Replication with Cryo-Electron Microscopy on HTC

May 20, 2019, 3:55 PM
15m
H.F. DeLuca Forum (Discovery Building on the University of Wisconsin-Madison Campus)

H.F. DeLuca Forum

Discovery Building on the University of Wisconsin-Madison Campus

330 N Orchard St, Madison, WI, 53715

Speaker

Hong Zhan (Morgridge Institute for Research)

Summary (2-4 sentences)<br>Just a few informal sentences describing what you want to present.<br>No need to spend a lot of time on this! You can change it later.

Recent rapid imaging processing techniques have been accelerating data analysis across scientific fields, including cryo-EM imaging in structural biology. Fast Cryo-EM data generation rate and heavy computational tasks in CryoEM work pipelines constraint efficient Cryo-EM data interpretation. Nowadays, a variety of infrastructures that rely on supercomputer clusters have been introduced to many scientific disciplinaries, including astronomy, geography, artificial intelligence, genetics, and structural biology, etc., which benefits researchers to retrieve desired outputs efficiently by taking advantage of large computational resources. To facilitate Cryo-EM data analysis, hereby, I established a working pipeline on the high-throughout compute (HTC) platform at the Center for High-Throughput Computing (CHTC) of University of Wisconsin-Madison to identify a high-resolution structure of RNA virus genome replication machinery by using Cryo-sub-tomogram averaging method.

Availability of the Speaker<br>Let us know if there are times you CANNOT present,<br>prehaps because you need to leave for the airport early, etc.

Monday

Primary author

Hong Zhan (Morgridge Institute for Research)

Presentation materials